The objective of this thesis project is to synthesize 1,2-disubstituted cyclopropene compounds from internal alkynes and diazoacetate compounds via (2÷1] cycloaddition reactions catalyzed by rhodium acetate (Rh2(OAc)4). To date, there is no known synthetic transformation to achieve this substitution pattern. 1,2-disubstituted cyclopropene compounds are versatile synthetic intermediates because their functionalization enables further synthetic manipulation. In this work, three cyclopropene compounds were synthesized using this methodology. Their syntheses are described herein.
Department, Program, or Center
School of Chemistry and Materials Science (COS)
Higgins, Kate E., "Synthesis of Polyfunctionalized 1,2-Disubstituted Cyclopropene Compounds" (2010). Thesis. Rochester Institute of Technology. Accessed from
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