Abstract

Tamoxifen has a backbone structure of triphenylethylene and is a drug that has been used for over 20 years to treat patients with breast cancer. It has been discussed in the literature that the C=C formation would be the desired synthetic approach because of its flexibility in the introduction of suitable functional groups using readily available reagents. Solid-phase combinatorial approach is adopted for the purpose of product diversity and simplicity in product analysis. This research focused on optimization of each reaction step in the Wittig mechanism to overcome low yield caused by employing solid-state chemistry and the steric hindrance of C=C formation. It has been discovered that commercially available polystyrene-triphenylphosphine resins require extreme reaction conditions and may not be applicable for the pharmaceutical industry.

Library of Congress Subject Headings

Tamoxifen; Combinatorial chemistry; Wittig reaction

Publication Date

2003

Document Type

Thesis

Student Type

Graduate

Degree Name

Chemistry (MS)

Department, Program, or Center

School of Chemistry and Materials Science (COS)

Advisor

Kay Turner

Comments

Physical copy available from RIT's Wallace Library atRS419 .L44 2003

Campus

RIT – Main Campus

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