An in vitro assay has been developed to measure bacterial uptake by rat alveolar macrophages. The assay is used to study the effect of a diet rich in high omega-6 linoleic acid on the phagocytic response of the macrophages obtained from young and old rats. Within the range of diets studied, no significant difference (p<0.05) is observed in the phagocytic capability of macrophages from young rats. Significant difference is observed between diet groups for the old rats (p<0.05), with the group on a fat-rich diet showing suppressed phagocytic response. Significant difference is also found between age groups for the same diet (p<0.05), older animals showing suppressed response.
Library of Congress Subject Headings
Macrophages; Lipids in nutrition; Immunity--Nutritional aspects
Department, Program, or Center
School of Chemistry and Materials Science (COS)
Mehta, Sangeeta R., "Effect of dietary lipids on rat alveolar macrophage function" (1991). Thesis. Rochester Institute of Technology. Accessed from
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