Nitroxide spin labels can be useful as oxygen probes since the shape of the characteristic three line electron spin resonance (ESR) spectrum broadens in the presence of molecular oxygen. In order to use these probes in. vivo to measure oxygen content of tumors, contact of toxic nitroxides with tissues must be prevented. This study describes synthesis and characterization of several styrene/maleic anhydride copolymers containing grafted 2,2,6,6-tetramethyl-4-aminopiperidine-1- oxyl (TEMPO) spin probes. Infrared (IR) spectroscopy was used to determine the structure of the copolymers. ESR spectroscopy was used to contrast the free radical activity of the copolymer in an nitrogen-rich and oxygen-rich environment. The changes observed in the ESR spectra were that dissolved oxygen noticeably broadens the peaks, but significant free radical activity remains in the copolymers. Attempts to graft TEMPO to 92/8 [styrene/maleic anhydride] copolymers achieved 67% success and to 50/50 [styrene/maleic anhydride] copolymers achieved k0% success.
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Department, Program, or Center
School of Chemistry and Materials Science (COS)
McCarthy, Christopher, "Synthetic routes towards spin probe-grafted copolymers" (1993). Thesis. Rochester Institute of Technology. Accessed from
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