Abstract

This research project had two major goals. Selected members of six groups of clinically useful drugs were obtained to develop and optimize reverse-phase isocratic high-performance liquid chromatographic (HPLO separations using the Hewlett Packard Series 1090 M HPLC. All optimized methods displayed excellent resolution between compounds within a method. Each optimized drug assay developed, displayed good linearity and precision. The second and primary goal of this research project was to provide RIT with a teaching tool. These optimized separations were incorporated into six laboratory experiments, written in a format that RIT's undergraduate students of Medical Technology could easily follow and complete in one three hour student laboratory session. Each laboratory experiment is characterized by being a fast, simple, easy, and reliable reverse phase isocratic HPLC separation of select members of these drug groups that can be identified and quantitated in serum or plasma.

Library of Congress Subject Headings

Drugs--Analysis; Drugs--Analysis--Experiments; Chromatographic analysis--Experiments; Clinical chemistry--Experiments

Publication Date

5-1-1988

Document Type

Thesis

Department, Program, or Center

School of Chemistry and Materials Science (COS)

Advisor

Aumer, James

Comments

Note: imported from RIT’s Digital Media Library running on DSpace to RIT Scholar Works. Physical copy available through RIT's The Wallace Library at: RB56 .H544 1988

Campus

RIT – Main Campus

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