Abstract
As the research of disordered proteins progresses and more disordered protein sequences are discovered, an optimal substitution matrix for the alignment of these sequences must be elucidated. The currently used substitution matrices, PAM and BLOSUM, are ideal for the alignment of general protein sequences. But it is discovered that this set of matrices is not adequate for the specific alignment of disordered protein sequences. By implementing genetic algorithms, a substitution matrix improved for the alignment of disordered proteins has been achieved. The genetic algorithm determined matrix performed two times better when compared to BLOSUM62 and PAM250.
Library of Congress Subject Headings
Proteins--Structure--Mathematical models; Genetic algorithms
Publication Date
4-24-2013
Document Type
Thesis
Advisor
Osier, Michael
Recommended Citation
Kim, Dong, "Determining a substitution matrix for the alignment of disordered proteins" (2013). Thesis. Rochester Institute of Technology. Accessed from
https://repository.rit.edu/theses/4317
Campus
RIT – Main Campus
Plan Codes
BIOINFO-MS
Comments
Note: imported from RIT’s Digital Media Library running on DSpace to RIT Scholar Works in December 2013. Physical copy available from RIT's Wallace Library at QP551 .K46 2013