Microarray analyses were performed to compare the gene expression profiles of wild-type and mutant strains of Tetrahymena thermophila. These studies suggest that, in Tetrahymena, ubiquitylation of histone H2B is not required for H3K4 methylation. Even though the E2 ubiquitin-conjugating enzyme Ubc2 and the E3 ubiquitin ligase Bre1 are required for H2B ubiquitylation, these two enzymes affect the expression of a much broader spectrum of genes than H2B ubiquitylation, suggesting that Ubc2 and Bre1 are involved in pathways other than H2B ubiquitylation in Tetrahymena.
Library of Congress Subject Headings
Tetrahymena--Genetics; Gene expression; Mutation (Biology)
Department, Program, or Center
Biomedical Sciences (CHST)
Wang, Zhe, "Microarray analysis of gene expression profiles of tetrahymena H2B ubiquitylation mutant strains" (2010). Thesis. Rochester Institute of Technology. Accessed from
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