Abstract
Background
The prevalence ratio (PR) and incidence rate ratio (IRR) of nonmotor symptoms (NMS) were calculated for early Parkinson's disease (PD) versus non-PD from 2 observational studies.
Methods
NMS were assessed through the self-reported Non-Motor Symptom Questionnaire in the online Fox Insight study and through self- and clinician-rated scales in the Parkinson's Progression Marker Initiative (PPMI) study. Age- and sex-adjusted/matched PR and IRR were estimated for each NMS by PD status using Poisson regression.
Results
Most NMS occurred more frequently in PD. Among 15,194 Fox Insight participants, sexual dysfunction had the largest adjusted PR (12.4 [95% CI, 6.9–22.2]) and dysgeusia/hyposmia had the largest adjusted IRR over a 2-year median follow-up (17.0 [95% CI, 7.8–37.1]). Among 607 PPMI participants, anosmia had the largest PR (16.6 [95% CI, 6.1–44.8]). During the 7-year median follow-up, hallucinations had the largest IRR (13.5 [95% CI, 6.3–28.8]).
Conclusion
Although many NMS are more common in early PD than in non-PD, their occurrence may differ with time (hallucinations) or data collection methods (sexual dysfunction).
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Publication Date
8-4-2022
Document Type
Article
Department, Program, or Center
Science and Mathematics (NTID)
Recommended Citation
Paracha, M., Herbst, K., Kieburtz, K. and Venuto, C.S. (2022), Prevalence and Incidence of Nonmotor Symptoms in Individuals with and Without Parkinson's Disease. Mov Disord Clin Pract, 9: 961-966. https://doi.org/10.1002/mdc3.13533
Campus
RIT – Main Campus
