Ethanol Extract of Blighia Sapida Stem Bark Show Remarkable Prophylactic Activity in Experimental Plasmodium berghei-Infected Mice.

Authors

Olayinka O. Otegbade, Ladoke Akintola University of Technology
Johnson A. Ojo, Ladoke Akintola University of Technology
Dolapo I. Adefokun, Ladoke Akintola University of Technology
Oyindamola O. Abiodun, University of Ibadan
Bolaji N. Thomas, Rochester Institute of TechnologyFollow
Olusola Ojurongbe, Ladoke Akintola University of Technology

Abstract

This work explores the antiplasmodial potential of ethanol extract of Blighia sapida (Lin. Sapindaceae) in chloroquine (CQ)- resistant Plasmodium berghei (ANKA strain)–infected mice. Chloroquine-resistant (ANKA) strain of P berghei was inoculated intraperitoneally into Swiss albino mice. Mice were treated orally for 4 consecutive days, before and after inoculation (prophylactic, suppressive, and curative models) with graded doses of the plant extracts with Artemether-Lumefantrine (Coartem) as control. Prophylactically, the extract showed a remarkable activity in the chemosuppression of P berghei parasites (P

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Publication Date

2017

Comments

© The Authors 2017

This article was originally published in Drug Target Insights and is available here: https://doi.org/10.33393/dti.2017.1365

Document Type

Article

Department, Program, or Center

Biomedical Sciences (CHST)

Recommended Citation

OtegbadeO. O., OjoJ. A., AdefokunD. I., AbiodunO. O., ThomasB. N., & OjurongbeO. (2017). Ethanol Extract of Blighia sapida Stem Bark Show Remarkable Prophylactic Activity in Experimental Plasmodium berghei-Infected Mice. Drug Target Insights, 11(1). https://doi.org/10.33393/dti.2017.1365

Campus

RIT – Main Campus