Abstract

The objective of this thesis project is to synthesize 1,2-disubstituted cyclopropene compounds from internal alkynes and diazoacetate compounds via (2÷1] cycloaddition reactions catalyzed by rhodium acetate (Rh2(OAc)4). To date, there is no known synthetic transformation to achieve this substitution pattern. 1,2-disubstituted cyclopropene compounds are versatile synthetic intermediates because their functionalization enables further synthetic manipulation. In this work, three cyclopropene compounds were synthesized using this methodology. Their syntheses are described herein.

Publication Date

8-2010

Document Type

Thesis

Student Type

Graduate

Degree Name

Chemistry (MS)

Department, Program, or Center

School of Chemistry and Materials Science (COS)

Advisor

Michael Coleman

Advisor/Committee Member

Christina Collison

Advisor/Committee Member

Paul Craig

Campus

RIT – Main Campus

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