The purpose of this research was to evaluate an alternative to polyvinyl chloride based packaging materials for pharmaceutical blister packaging that is neither harmful to the environment nor corrosive to the equipment used in pharmaceutical packaging. Olefin structures (PP/COC/PP) were tested and compared to halogen based material (PVC/PVDC) using the following criteria: • Moisture Vapor Transmission Rate (MVTR) • Vacuum leak test • Peel strength test • Machine ability and form-ability on an Uhlmann UPS4 thermoformer • Layer distribution • Financial impact Cyclic Olefin Copolymers (COC) was proven to have the properties required to adequately protect the product while being environmentally safer than PVDC and CTFE.
Library of Congress Subject Headings
Polyolefins; Plastic films; Blister packs; Plastics in packaging; Drugs--Packaging; Polyvinyl chloride--Environmental aspects; Drug packaging industry--Environmental aspects
Department, Program, or Center
Packaging Science (CAST)
Khalil, Amgad, "Cyclic Olefin Copolymer (COC) in the pharmaceutical industry" (2004). Thesis. Rochester Institute of Technology. Accessed from
RIT – Main Campus