An in vitro assay has been developed to measure bacterial uptake by rat alveolar macrophages. The assay is used to study the effect of a diet rich in high omega-6 linoleic acid on the phagocytic response of the macrophages obtained from young and old rats. Within the range of diets studied, no significant difference (p<0.05) is observed in the phagocytic capability of macrophages from young rats. Significant difference is observed between diet groups for the old rats (p<0.05), with the group on a fat-rich diet showing suppressed phagocytic response. Significant difference is also found between age groups for the same diet (p<0.05), older animals showing suppressed response.

Library of Congress Subject Headings

Macrophages; Lipids in nutrition; Immunity--Nutritional aspects

Publication Date


Document Type


Department, Program, or Center

School of Chemistry and Materials Science (COS)


Wandge, John


Note: imported from RIT’s Digital Media Library running on DSpace to RIT Scholar Works. Physical copy available through RIT's The Wallace Library at: QR185.8.M3 S26 1991


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