Abstract
The synthesis of a combinatorial library of a-amide sulfone derivatives of phenylalanine was achieved using a solid phase synthesis approach. A multistep reaction sequence was used to introduce two sites of diversity, beginning with phenylalanine as the template attached to ArgoGel-Wang resin. The initial solid phase reaction studies were monitored using nanoprobe NMR and the reaction progress for library synthesis was monitored using a duplicate of one of library members as an analytical control sample. The complete library was evaluated by HPLC-DAD and HPLC-MS analysis of cleaved products. Selected members of the library were characterized using FAB MS/MS and !H NMR. All of the library compounds were synthesized and shown to be the correct desired products. The purity of the library compounds ranged from 3 1 .4% to 88.8% based on area % using HPLC.
Library of Congress Subject Headings
Combinatorial chemistry; Phenylalanine
Publication Date
5-1-1999
Document Type
Thesis
Department, Program, or Center
School of Chemistry and Materials Science (COS)
Advisor
Turner, Kay
Recommended Citation
Hoteling, Andrew, "A Combinatorial library of (alpha)-amide sulfone derivatives of phenylalanine" (1999). Thesis. Rochester Institute of Technology. Accessed from
https://repository.rit.edu/theses/6034
Campus
RIT – Main Campus
Comments
Note: imported from RIT’s Digital Media Library running on DSpace to RIT Scholar Works. Physical copy available through RIT's The Wallace Library at: RS419 .H68 1999