Abstract

Congenital cardiovascular malformations are one of the major contributors to infant mortality in the United States today. Defects in the cardiovascular system are evident at very early stages in the developing embryo, yet there exists no substantial diagnostic tool(s) for recognizing defects at these early stages. Cardiac morphogensis occurs throughout the pre-innervated period of embryonic development. It is speculated that the flow of blood during the early embryonic stages plays an important role in the development of the cardiovascular system. Blood flow is a possible mechanism for communication between the heart and vasculature, contributing to cardiac development. The objective of this study is to investigate ventricular-vascular coupling across the conotruncus and aortic arches using mathematical models to simulate experimental hemodynamic data from a Stage 21 White Leghorn chick embryo. Lumped-parameter hydraulic models of the embryonic vasculature are tested for their ability to predict experimental data using Least Squares minimization techniques. This research explores the use of linear parametric models as an effective tool in characterizing embryonic hemodynamics.

Library of Congress Subject Headings

Cardiovascular system--Mathematical models; Hemodynamics--Mathematical models; Congenital heart disease--Diagnosis--Mathematical models; Biomedical engineering

Publication Date

9-1-1996

Document Type

Thesis

Department, Program, or Center

Mechanical Engineering (KGCOE)

Advisor

Kempski, Mark

Advisor/Committee Member

Kochersberger, Kevin

Advisor/Committee Member

Hennessey, Michael

Comments

Note: imported from RIT’s Digital Media Library running on DSpace to RIT Scholar Works. Physical copy available through RIT's The Wallace Library at: QP102 .B38 1996

Campus

RIT – Main Campus

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