Author

I-en Lin

Abstract

Cardiac pump function is closely linked to myocardial oxygen supply during the cardiac cycle. Variations in cardiac output must be met with concurrent shifts in tissue blood flow if changing myocardial oxygen requirements are to be satisfied. Of particular importance is the adequate perfusion of the left ventricular myocardium. Experimental evidence indicates that some ninety percent of left ventricular oxygen demand is generated during systolic contraction of the myocardium. Paradoxically, blood flow measurements in the left coronary artery suggest minimal systolic perfusion. The asynchronous, phasic character of left coronary blood flow and myocardial oxygen demand has prompted much research into the time dependent origins of coronary flow impedance. Various (sometimees conflicting) theories have been proposed, all of which suggest tissue blood delivery is significantly influenced by mechanical interactions between the myocardium and its embedded vascular network. Such interactions become particularly acute during systole, where myocardial contraction produces deformations and stress contractions which influence embedded vessel patency, coronary flow impedance, and effective driving pressure.

Publication Date

4-1-1989

Document Type

Thesis

Department, Program, or Center

Mechanical Engineering (KGCOE)

Advisor

Kempski, Mark

Advisor/Committee Member

Ghoneim, Hany

Advisor/Committee Member

Torok, Joseph

Comments

Note: imported from RIT’s Digital Media Library running on DSpace to RIT Scholar Works in December 2013.

Campus

RIT – Main Campus

Share

COinS