Modulation of kidney cyclic AMP pdase by diuretics and antihypertensives was studied. It was found that spironolactone activates pdase and that furosemide, ethacrynic acid, triameterine , quinethazone, metolazone, chlorothiazide, propranolol and hydralazine, inhibit pdase. The relative tissue specificity (medulla or cortex) for some of the compounds appears to be in agreement with the proposed sites of drug action via pharmocological mechanisms which do not involve Inter action with cAMP pdase . The specific activity of pdase in the medulla was found to be double that in the cortex. Pdase was found to be a complex enzyme with at least two separate sets of kinetic parameters.
Library of Congress Subject Headings
Hypotensive agents; Renal pharmacology; Diuretics
Department, Program, or Center
School of Chemistry and Materials Science (COS)
Fouquet, Gary, "Modulation of cyclic amp phosphodiesterase" (1977). Thesis. Rochester Institute of Technology. Accessed from
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