A method towards the total synthesis of eletefine is described. Two related convergent syntheses are explained which divide the molecule into two fragments. Improvements towards the synthesis of a bis-functionalized isoquinoline fragment are explained. Expansion on the knowledge and understanding of the isoquinoline system is also described. The synthesis illustrated entails a bromination of a triflate functionalized isoquinoline system and a regio-selective Sonogashira reaction. Suggestions towards the completion of the total synthesis are prescribed.
Library of Congress Subject Headings
Bromination; Alkaloids--Synthesis; Isoquinoline
Department, Program, or Center
School of Chemistry and Materials Science (COS)
Ahmed, Ijaz, "Studies toward the total synthesis of eletefine" (2010). Thesis. Rochester Institute of Technology. Accessed from
RIT – Main Campus