The pharmacokinetic behavior of MRI contrast agents determines the temporal variation of T1 and T2 values in tumor and normal tissues. In most cases these variations occur rapidly during the first few minutes after contrast injection. We have developed a model to study the effect of TI and T2 variations during image acquisition for a spin-echo pulse sequence. The method is based on the understanding that the Free Induction Decay (FID) measurements in MRI are samples of the 2D fourier space along k trajectories, determined by the gradient fields. With the experimental TI and T2 data for Gd-DTPA in rat liver and liver tumor, the effect of temporal variations of TI and T2 on the final image contrast is illustrated for standard spin-echo imaging pulse sequence (Refer to PDF file for exact formulas).
Date of creation, presentation, or exhibit
Department, Program, or Center
Chester F. Carlson Center for Imaging Science (COS)
Rao, Navalgund, "Variations in T1 and T2 due to MRI contrast agents: effect on image contrast" (1989). Accessed from
RIT – Main Campus