Navalgund Rao


The pharmacokinetic behavior of MRI contrast agents determines the temporal variation of T1 and T2 values in tumor and normal tissues. In most cases these variations occur rapidly during the first few minutes after contrast injection. We have developed a model to study the effect of TI and T2 variations during image acquisition for a spin-echo pulse sequence. The method is based on the understanding that the Free Induction Decay (FID) measurements in MRI are samples of the 2D fourier space along k trajectories, determined by the gradient fields. With the experimental TI and T2 data for Gd-DTPA in rat liver and liver tumor, the effect of temporal variations of TI and T2 on the final image contrast is illustrated for standard spin-echo imaging pulse sequence (Refer to PDF file for exact formulas).

Date of creation, presentation, or exhibit



Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2 (1989) 584-586 "Variations in T1 and T2 due to MRI contrast agents," Proceedings of the Annual International Conference of the IEEE Engineering in Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century. The Institute of Electrical and Electronics Engineers (IEEE). Held in Seattle, Washington: 9-12 November 1989. ©1989 Institute of Electrical and Electronics Engineers (IEEE). Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE. This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. The author would like to thank Dr. D. D. Stark and Dr. R. E. Hendrick for providing the experimental TI and T2 data on rat model. This research was supported by NIH fellowship grant No. 253540. ISSN: 0739-5175 Note: imported from RIT’s Digital Media Library running on DSpace to RIT Scholar Works in February 2014.

Document Type

Conference Proceeding

Department, Program, or Center

Chester F. Carlson Center for Imaging Science (COS)


RIT – Main Campus